Drexel Magazine's Top 40 Under 40 Nominee Dr. Allison Andrews

https://drexelmagazine.org/2021/allison-andrews/

https://drexelmagazine.org/2021/allison-andrews/

Allison M. Andrews’ interest in understanding human physiology has propelled her to investigate ways to simulate tissue environments on a chip. From her days as a graduate student at Drexel, she became fascinated with the biomechanics of fluid flow within the vasculature and the commonality that the vascular system has with so many ubiquitous health ailments such as high blood pressure, diabetes, strokes and cancer. Her unique perspective as a biomedical engineer has resulted in two patents, funding from the National Institutes of Health (NIH), numerous publications in high-impact journals and other accolades. As an assistant professor at the Lewis Katz School of Medicine at Temple University, she has developed a premier program that focuses on the use of microfluidics, tissue engineering, and 3D printing to recreate the neurovascular unit (NVU) on a chip. “These powerful tools have endless applications, but I’m most excited about the exquisite details such devices can provide for studying neuroinflammation, such as that seen in HIV infection, sepsis, neurotrauma or multiple sclerosis,” she says. Her work hasn’t been lost on the NIH; in 2019, Andrews received the highly competitive and coveted NIH Mentored Research Scientist Development Award to explore immune-endothelial interactions. Notably, she has expanded her purview to include the study of cellular events associated with SARS-CoV-2 in order to better understand the neurological deficits seen in COVID-19 patients. Her co-authored studies on SARS-CoV-2 in the December issue of the Neurobiology of Disease is currently one of the top-read and top–cited papers in the journal.

New Publication

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The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier.

Authors: Tetyana P Buzhdygan, PhD; Brandon J DeOre, BS; Abigail Baldwin-Leclair, BS; Trent A Bullock, BS, MA; Hannah McGary, BS; Jana A Khan, BS; Roshanak Razmpour, BS; Jonathan F Hale, BS, MA; Peter A Galie, PhD; Raghava Potula, PhD; Allison M Andrews, PhD; Servio H Ramirez, PhD

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