“Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we fear less.”

-Marie Curie, Physicist & Chemist, Nobel Prize Recipient

Research Publications

Complete List of Published Work in MyBibliography: http://www.ncbi.nlm.nih.gov/sites/myncbi/10A9T5mlhmT5c/bibliography/47815547/public/?sort=date&direction=ascending

1)    Galpayage Dona, K.N.U., Benmassaoud, M.M., Gipson, C.D., McLaughlin, J.P. Ramirez, S.H., and Andrews, A.M. Something to talk about; crosstalk disruption at the neurovascular unit during HIV infection of the CNS NeuroImmune Pharm Ther. doi:10.1515/nipt-2024-0003

2)    Paone, L.S., Szkolnicki, M., DeOre B.J., Tran, K.A., Goldman, N., Andrews, A.M., Ramirez, S.H., and Galie, P.A. Effects of Drag-Reducing Polymers on Hemodynamics and Whole Blood-Endothelial Interactions in 3D-Printed Vascular Topologies. ACS Appl Mater Interfaces. 2024 Mar 15. doi: 10.1021/acsami.3c17099.

3)    Leonard, B., Galpayage Dona, K.N.U., Shuvaev, V., Muzykantov, V., Andrews, A.M., and Ramirez, S.H., Engineered dual antioxidant enzyme complexes targeting ICAM-1 on brain endothelium reduces brain injury associated neuroinflammation Bioengineering 2024, 11(3), 200; https://doi.org/10.3390/bioengineering11030200

4)    Bullock, T.A., Galpayage Dona, K.N.U., Hale, J.F., Morales, P., Jagerovic, N., Andrews, A.M., Ramirez, S.H. Activation of CB2R by synthetic CB2R agonist, PM289, improves brain endothelial barrier properties, decreases inflammatory response and enhances endothelial repair NeuroImmune Pharm Ther. 2023 Oct 16;2(4):387-400. doi: 10.1515/nipt-2023-0016. 

5)    Galpayage Dona, K.N.U, Ramirez, S.H. and Andrews, A.M. A next generation 3D tissue engineered model of the human brain microvasculature to study the blood brain barrier Bioengineering (Basel). 2023 Jul 8;10(7):817. doi: 10.3390/bioengineering10070817.

6)    Ramirez, S.H., Hale, J.H., McCarthy, S., Cardenas, C.L., Galpayage Dona, K.N.U., Hanlon, K.S., Hudry, E., De La Cruz, D., Ng, C., Das, S., Nguyen, D.M., Nammour, J., Bennett, R., Andrews, A.M., Musolino, P.L., and Maguire, C.A. An engineered AAV9 capsid mediates efficient in-vivo targeting and transduction of pericytes and smooth muscle cells of the cerebral vasculature Hum Gene Ther. 2023 Jun 27. doi: 10.1089/hum.2022.211

7)    DeOre B.J., Tran, K.A., Andrews, A.M., Ramirez, S.H., Galie, P.A. “SARS-CoV-2 spike protein disrupts blood-brain barrier integrity via RhoA activation” J Neuroimmune Pharmacol. 2021 Oct 23:1-7. doi: 10.1007/s11481-021-10029-0. 

8)    Ramirez, S.H., Buzhdygan, T.P., Hale, J.F., Cheng, L., Li, G., Hoover-Hankerson, B., Razmpour, R., Sriram, U., Su, L., Potula, R., Andrews, A.M. Extracellular microvesicles released from brain endothelial cells are detected in animal models of HIV-1 signifying unresolved inflammation J Neuroimmune Pharmacol. 2021 Aug 26. doi: 10.1007/s11481-021-10008-5.

9)    Galpayage Dona, K.N.U, Hale, J.F. , Salako, T.T., Anandanatarajan, A., Tran, A.K., DeOre, B.J., Galie, P.A, Ramirez, S.H. and, Andrews, A.M “The use of Tissue Engineering to fabricate perfusable 3D brain microvessels in vitro” Front Physiol. 2021; 12: 715431. DOI: 10.3389/fphys.2021.715431

10)    Buzhdygan, T.P., Rodrigues, C.R., Andrews, A.M., Rawls, S.M. and Ramirez, S.H. The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties J Neuroinflammation. 2021 Mar 1;18(1):63. doi: 10.1186/s12974-021-02116-z. PubMed PMID: 33648543; PubMed Central PMCID: PMC7923670.

11)    Wu, L., Islam, M.R., Lee, J., Takase, H., Guo, S., Andrews, A.M., Buzhdygan T.P., Mathew, J., Li, W., Arai, K., Lo, E.H., Ramirez, S.H., and Lok, J., ErbB3 is a critical regulator of cytoskeletal dynamics in brain endothelial cells: implications for modulation of the blood brain barrier. J Cereb Blood Flow Metab. 2021 Feb 14;271678X20984976.doi: 10.1177/0271678X20984976.

12)    Buzhdygan, T.P., DeOre, B.J., Baldwin-Leclair, A., Bullock, T.A., McGary, H., Kahn, J.A., Razmpour, R., Hale, J.F., Galie, P.A., Potula, R., Andrews, A.M., and Ramirez, S.H. The SARS-CoV-2 spike protein alters barrier function in an in-vitro model of the human blood-brain barrier. Neurobiol Dis. 2020 Dec;146:105131. doi: 10.1016/j.nbd.2020.105131. Epub 2020 Oct 11. PubMed PMID: 33053430; PubMed Central PMCID: PMC7547916.

13)    Cannella, L.A., Andrews, A.M., Razmpour, R., McGary, M., Corbet, C., Kahn, J., Ramirez, S.H. Reward and Immune Responses in Females Following Experimental Adolescent Traumatic Brain Injury Behav Brain Res. 2020 Feb 3;379:112333. doi: 10.1016/j.bbr.2019.112333. PubMed PMID: 31682867; PubMed Central PMCID: PMC6938678

14) Cannella, L.A., Andrews, A.M, Tran, F., Razmpour, R., McGary, H., Collie, C., Tsegaye, T., Maynard, M., Kaufman, M.J., Rawls, S.M. and Ramirez, S.H. Experimental Traumatic Brain Injury during Adolescence Enhances Cocaine Rewarding Efficacy and Dysregulates Dopamine and Neuroimmune Systems in Brain Reward Substrates J Neurotrauma. 2019 Aug 21. doi: 10.1089/neu.2019.6472. PubMed PMID: 31347447; PubMed Central PMCID: PMC6921296.

15) Lutton, E.M., Farney, S.K., Andrews, A.M., Shuvaev, V.V., Chuang G.Y., Muzykantov, V.R., Ramirez, S.H. Endothelial targeted strategies to combat oxidative stress: improving outcomes in traumatic brain injury Front. Neurol., 06 June 2019 https://doi.org/10.3389/fneur.2019.00582 PubMed PMID: 31275220; PubMed Central PMCID: PMC6593265.

16) Ramirez, S.H., Andrews, A.M., Paul, D., and J.S. Pachter. Extracellular vesicles: Mediators and biomarkers of pathology along CNS barriers. Review. Fluids Barriers CNS. 2018 Jul 1;15(1):19. doi: 10.1186/s12987-018-0104-7. PubMed PMID: 29960602; PubMed Central PMCID: PMC6026502.

17) Andrews, A.M, Lutton E.M, Cannella, L.A., Reichenbach, N., Razmpour, R., Seasock, M.J., Kaspin, S.J., Merkel, S.F., Langford, D. Persidsky, Y., and Ramirez, S.H. Characterization of Human Fetal Brain Endothelial Cells Reveals Barrier Properties Suitable for In Vitro Modeling of the BBB with Syngenic Co-Cultures. Journal of cerebral blood flow and metabolism. 2018; 38(5):888-903.1177/0271678X17708690. PubMed PMID: 28534661; PubMed Central PMCID: PMC5987936.

18) Merkel, S.F.*, Andrews, A.M.*, Lutton, E.M., Razmpour, R., Cannella, L.A., and Ramirez, S.H. Dexamethasone Attenuates the Enhanced Rewarding Effects of Cocaine following experimental Traumatic Brain Injury. Cell transplantation. 2017; 26(7):1178-1192. PubMed PMID: 28933216; PubMed Central PMCID: PMC5447499.*denotes equal contribution

19) Lutton, E.M., Razmpour, R., Andrews, A.M., Cannella, L.A., Shuvaev, V.V., Muzykantov, V.R., Ramirez, S.H. Acute administration of catalase targeted to ICAM-1 attenuates neuropathology in experimental traumatic brain injury. Sci Rep. 2017 Jun 19;7(1):3846. doi: 10.1038/s41598-017-03309-4. PubMed PMID: 28630485; PubMed Central PMCID: PMC5476649.

20) Sagar, D., Signh, N., Ginwala, R., Huang, X., Philip, R., Nagarkatti, M., Nagarkatti, P., Neumann, K., Ruland, J., Andrews, A.M., Ramirez, S.H., Khan, Z., and P. Jain. Antibody blockade of CLEC12A delays EAE onset, attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity. Sci Rep. 2017 Jun 2;7(1):2707. doi: 10.1038/s41598-017-03027-x. PubMed PMID: 28578388; PubMed Central PMCID: PMC5457463.

21) Andrews A.M., Muzorewa, T.T, Zaccheo, K.A., Buerk D.G., Jaron D. and Barbee K.A. Cholesterol Enrichment Impairs Shear Stress-Induced Nitric Oxide Production by Inhibiting Capacitative Calcium Entry. Cel. Mol. Bioeng. 2017; 10(1):30-40 PubMed PMID: 28138348; PubMed Central PMCID: PMC5270765. 

22) Merkel, S.F., Andrews, A.M., Lutton, E.M., Mu, D., Hyman, B.T., Maguire, C.A. and Ramirez, S.H. Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells J Neurochem. 2017 140(2):216-230 PubMed PMID: 27718541; PubMed Central PMCID: PMC5298820.

23) Andrews, A.M., Lutton, E.M, Merkel, S.F., Razmpour, R., and Ramirez, S.H., Mechanical injury induces brain endothelial-derived microvesicle release: Implications for cerebral vascular injury during traumatic brain injury. Front. Cell. Neurosci., 29 February 2016 10:43 PubMed PMID: 26973460; PubMed Central PMCID: PMC4770030.

24) Andrews A.M. and Rizzo, V. Mechanism of Microparticle-induced Activation of the Vascular Endothelium Requires Caveolin-1/Caveolae. PlosOne 2016 Feb 18;11(2):e0149272. PubMed PMID: 26891050; PubMed Central PMCID: PMC4758735.

25) Wu, L., Ramirez, S.H., Andrews, A.M., Leung, W.,Itoh, K., Wu, J., Lo, E.H. and Lok, J. Neuregulin1-β prevents IL-1β induced endothelial barrier dysfunction by modulating RhoA activation and myosin light chain phosphorylation. J Neurochem. 2016 Jan;136(2):250-7 PubMed PMID: 26438054; PubMed Central PMCID: PMC4959605.

26) Watters, A., Rom, S., Hill, J., Dematatis, M.K., Zhou, Y., Merkel, S.F., Andrews, A.M., Cena, J., Potula, R., Andrew, S., Son, Y., Persidsky, Y., Ramirez, S.H. Identification and dynamic regulation of tight junction protein expression in human neural stem cells. Stem Cells Dev. 2015 Jun 15;24(12):1377-89 PubMed PMID: 25892136; PubMed Central PMCID: PMC4485374.

27) Andrews A.M., Jaron D., Buerk D.G. and Barbee K.A. Shear stress-induced Nitric Oxide (NO) production is dependent on ATP autocrine signaling and capacitative calcium entry activation. Cellular and Molecular Bioengineering: 2014 Dec 1;7(4):510-520 PubMed PMID: 25386222; PubMed Central PMCID: PMC4224574.

28) Zeng Y., Waters M., Andrews A., Honarmandi P., Ebong E., Rizzo V., and Tarbell J. Fluid Shear Stress induces the Clustering of Heparan Sulfate via Mobility of Glypican-1 in Lipid Rafts. Am J Physiol Heart Circ Physiol. 2013 Sep;305(6):H811-20 PubMed PMID: 23851278; PubMed Central PMCID: PMC3761343.

29) Kemeny S.F., Figueroa D.S., Andrews A.M., Barbee K.A., Clyne A.M. Glycated collagen alters endothelial cell actin alignment and nitric oxide release in response to fluid shear stress. J Biomech. 2011 44(10): 1927-35, 2011 PMID: 21555127

30) Andrews A.M., Jaron D., Buerk D.G., Kirby P.L., Barbee K.A. Direct, Real-Time Measurement of Shear Stress-Induced Nitric Oxide Produced from Endothelial Cells In Vitro. Nitric Oxide 2010 23(4): 335-342, 2010 PubMed PMID: 20719252; PubMed Central PMCID: PMC2965060. 

Disclaimer of Proprietary Rights: www.andrewslaboratory.com may contain proprietary and confidential information including trademarks, service marks and patents protected by intellectual property laws and international intellectual property treaties.  Andrewslaboratory.com authorizes you to view and make a single copy of portions of its content for offline, personal, non-commercial use.  Our content may not be sold, reproduced, or distributed without our written permission.  Any third-party trademarks, service marks and logos are the property of their respective owners.  Any further rights not specifically granted herein are reserved.